In present study antiulcer activity of hydroalcoholic extract of Smilax zeylanica (SZE) roots was investigated in animal model of ulcer. Ulcer was induced by pylorus ligation and pylorus ligation with aspirin. SZE produced significant reductive effect on ulcer at 100, 200 and 400 mg/kg. Efficacy was assessed on the basis of total gastric volume, pH, total acidity, free acidity, ulcer index and percentage protection. It was observed that SZE significantly (P<0.05) reduced level of all parameters assessed in present investigation. From this study it can be concluded that hydroalcoholic extract of roots of Smilax zeylanica possess significant antiulcer activity.
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